{"id":352,"date":"2022-06-19T23:27:44","date_gmt":"2022-06-19T14:27:44","guid":{"rendered":"https:\/\/www.intmed2.med.kyushu-u.ac.jp\/gut\/?page_id=352"},"modified":"2022-06-19T23:35:19","modified_gmt":"2022-06-19T14:35:19","slug":"clinical_13","status":"publish","type":"page","link":"https:\/\/www.intmed2.med.kyushu-u.ac.jp\/gut\/clinical_13\/","title":{"rendered":"_13_\u6d88\u5316\u7ba1\u60aa\u6027\u30ea\u30f3\u30d1\u816b\u306b\u304a\u3051\u308b\u30de\u30a4\u30af\u30edRNA\u306e\u81e8\u5e8a\u7684\u610f\u7fa9\u306b\u95a2\u3059\u308b\u7814\u7a76"},"content":{"rendered":"
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\u5f53\u79d1\u306b\u304a\u3051\u308b\u81e8\u5e8a\u7814\u7a76\u304a\u3088\u3073\u6cbb\u7642 CLINICAL CASE STUDY<\/span><\/h2>\n<\/div>\n<\/div>\n
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\u6d88\u5316\u7ba1\u60aa\u6027\u30ea\u30f3\u30d1\u816b\u306b\u304a\u3051\u308b\u30de\u30a4\u30af\u30edRNA\u306e\u81e8\u5e8a\u7684\u610f\u7fa9\u306b\u95a2\u3059\u308b\u7814\u7a76<\/h4>\n

\u306f\u3058\u3081\u306b<\/h4>\n

\u6d88\u5316\u7ba1\u60aa\u6027\u30ea\u30f3\u30d1\u816b\u306b\u5bfe\u3057\u3001\u6297\u304c\u3093\u5264\u3084\u751f\u7269\u5b66\u7684\u88fd\u5264\u306b\u3088\u308b\u5316\u5b66\u7642\u6cd5\u3084\u624b\u8853\u3001\u653e\u5c04\u7dda\u7642\u6cd5\u3001\u6297\u83cc\u85ac\u306b\u3088\u308b\u30d4\u30ed\u30ea\u83cc\u9664\u83cc\u306a\u3069\u3001\u7d44\u7e54\u578b\u3084\u75c5\u671f\u306b\u5fdc\u3058\u3066\u69d8\u3005\u306a\u6cbb\u7642\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u4e00\u5b9a\u306e\u6307\u91dd\u306f\u307e\u3060\u5b9a\u3081\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u75c5\u6c17\u306e\u539f\u56e0\u306b\u3064\u3044\u3066\u3001\u3053\u308c\u307e\u3067\u306b\u30bf\u30f3\u30d1\u30af\u306e\u8a2d\u8a08\u56f3\u3068\u306a\u308b\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u304c\u591a\u304f\u8abf\u3079\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u6700\u8fd1\u306b\u306a\u3063\u3066\u3001\u30bf\u30f3\u30d1\u30af\u306b\u7ffb\u8a33\u3055\u308c\u306a\u3044\u5c0f\u3055\u306a\u907a\u4f1d\u5b50\u3067\u3042\u308b\u30de\u30a4\u30af\u30edRNA\u304c\u3001\u591a\u304f\u306e\u764c\u306e\u767a\u751f\u3084\u5236\u5fa1\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3068\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u4e00\u90e8\u306e\u60aa\u6027\u30ea\u30f3\u30d1\u816b\u306b\u304a\u3044\u3066\u3082\u30de\u30a4\u30af\u30edRNA\u306e\u767a\u73fe\u306e\u7a0b\u5ea6\u304c\u4e88\u5f8c\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u6d88\u5316\u7ba1\u306b\u767a\u751f\u3059\u308b\u591a\u304f\u306e\u60aa\u6027\u30ea\u30f3\u30d1\u816b\u306b\u304a\u3051\u308b\u30de\u30a4\u30af\u30edRNA\u306e\u5f79\u5272\u306f\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u3053\u306e\u7814\u7a76\u306e\u76ee\u7684\u306f\u6d88\u5316\u7ba1\u60aa\u6027\u30ea\u30f3\u30d1\u816b\u306e\u816b\u760d\u7d30\u80de\u306b\u304a\u3051\u308b\u30de\u30a4\u30af\u30edRNA\u767a\u73fe\u7570\u5e38\u304c\u3001\u75c5\u6c17\u306e\u9032\u884c\u5ea6\u3001\u6cbb\u7642\u306e\u52b9\u679c\u3084\u751f\u547d\u4e88\u5f8c\u306a\u3069\u306e\u81e8\u5e8a\u50cf\u3068\u95a2\u4fc2\u304c\u3042\u308b\u306e\u304b\u3069\u3046\u304b\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3067\u3059\u3002<\/p>\n<\/section>\n

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\u5bfe\u8c61<\/h4>\n

1970\u5e741\u67081\u65e5\u304b\u30892020\u5e743\u670831\u65e5\u307e\u3067\u306b\u4e5d\u5dde\u5927\u5b66\u75c5\u614b\u6a5f\u80fd\u5185\u79d1\u5b66\uff08\u65e7\u7b2c\u4e8c\u5185\u79d1\uff09\u3042\u308b\u3044\u306f\u6d88\u5316\u7ba1\u5185\u79d1\u306b\u901a\u9662\u3082\u3057\u304f\u306f\u5165\u9662\u3055\u308c\u305f\u60a3\u8005\u3055\u3093\u306e\u4e2d\u3067\u3001\u6d88\u5316\u7ba1\uff08\u80c3\u307e\u305f\u306f\u8178\uff09\u306e\u60aa\u6027\u30ea\u30f3\u30d1\u816b\uff08\u3073\u307e\u3093\u6027\u5927\u7d30\u80de\u578bB\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u3001MALT\u30ea\u30f3\u30d1\u816b\u3001\u6ffe\u80de\u6027\u30ea\u30f3\u30d1\u816b\u3001\u30de\u30f3\u30c8\u30eb\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u3001NK\/T\u7d30\u80de\u30ea\u30f3\u30d1\u816b\uff09\u3068\u8a3a\u65ad\u3055\u308c\u305f\u65b9400\u4f8b\u3092\u5bfe\u8c61\u3068\u3057\u307e\u3059\u3002
\n\u627f\u8a8d\u65e5\u4ee5\u964d\u306b\u8a3a\u65ad\u3055\u308c\u305f\u65b9\u306b\u3064\u3044\u3066\u306f\u8a3a\u65ad\u5f8c\u306b\u8aac\u660e\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u3001\u540c\u610f\u3092\u3044\u305f\u3060\u3044\u305f\u65b9\u306e\u307f\u3092\u5bfe\u8c61\u3068\u3057\u307e\u3059\u3002
\n\u672c\u7814\u7a76\u306e\u5bfe\u8c61\u8005\u3068\u306a\u308b\u3053\u3068\u3092\u5e0c\u671b\u3055\u308c\u306a\u3044\u65b9\u306f\u3001\u4e0b\u8a18\u9023\u7d61\u5148\u307e\u3067\u3054\u9023\u7d61\u304f\u3060\u3055\u3044\u3002<\/p>\n<\/section>\n

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\u7814\u7a76\u5185\u5bb9<\/h4>\n

\u672c\u7814\u7a76\u306f\u524d\u5411\u304d\u306e\u4ecb\u5165\u7814\u7a76\u30fb\u5f8c\u308d\u5411\u304d\u306e\u89b3\u5bdf\u7814\u7a76\u3068\u3057\u3066\u5b9f\u65bd\u3055\u308c\u307e\u3059\u3002\u8a3a\u65ad\u307e\u305f\u306f\u6cbb\u7642\u306e\u305f\u3081\u306b\u5185\u8996\u93e1\u691c\u67fb\u307e\u305f\u306f\u624b\u8853\u306e\u969b\u306b\u5f97\u3089\u308c\u305f\u6d88\u5316\u7ba1\u60aa\u6027\u30ea\u30f3\u30d1\u816b\u306e\u816b\u760d\u7d30\u80de\u306e\u4e00\u90e8\u3092\u7528\u3044\u3066\u3001\u30ea\u30f3\u30d1\u816b\u3067\u6700\u8fd1\u95a2\u9023\u304c\u3042\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u30de\u30a4\u30af\u30edRNA\u767a\u73fe\u7570\u5e38\u3092\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4\u89e3\u6790\u3084\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0PCR\u89e3\u6790\u3067\u8abf\u3079\u307e\u3059\u3002\u305d\u306e\u969b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u3068\u3057\u3066\u75c5\u5909\u90e8\u4ee5\u5916\u306e\u7d44\u7e54\u3092\u7528\u3044\u307e\u3059\u3002\u30ab\u30eb\u30c6\u3092\u53c2\u7167\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u3001\u81e8\u5e8a\u6240\u898b\uff08\u8a3a\u65ad\u6642\u5e74\u9f62\u3001\u6027\u5225\u3001\u6d78\u6f64\u81d3\u5668\u3001\u75c5\u6b74\u306b\u95a2\u3059\u308b\u60c5\u5831\u3001\u81e8\u5e8a\u75c5\u671f\u3001\u4e00\u822c\u72b6\u614b(performance status, B\u75c7\u72b6)\uff09\u3001\u8840\u6db2\u6240\u898b\uff08\u8840\u6db2\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u3001\u53ef\u6eb6\u6027IL-2\u53d7\u5bb9\u4f53\u3001LDH\u3001\u03b22\u30df\u30af\u30ed\u30b0\u30ed\u30d6\u30ea\u30f3\uff09\u3001\u611f\u67d3\u75c7\u306e\u6709\u7121\uff08\u30d8\u30ea\u30b3\u30d0\u30af\u30bf\u30fc\u3001\u30ad\u30e3\u30f3\u30d4\u30ed\u30d0\u30af\u30bf\u30fc\u3001C\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9\u3001\u5404\u7a2e\u5bc4\u751f\u866b\uff09\u3001\u75c5\u7406\u5b66\u7684\u6240\u898b\uff08\u30ea\u30f3\u30d1\u816b\u306e\u7d44\u7e54\u578b\u3001\u6ffe\u80de\u6027\u30ea\u30f3\u30d1\u816b\u3067\u306f\u7d44\u7e54\u30b0\u30ec\u30fc\u30c9\uff09\u3001\u6cbb\u7642\uff08\u6cbb\u7642\u958b\u59cb\u65e5\u3001\u6cbb\u7642\u65b9\u6cd5\u3001\u52b9\u679c\u4e0d\u5341\u5206\u6642\u306e\u8ffd\u52a0\u6cbb\u7642\uff09\u3001\u6cbb\u7642\u53cd\u5fdc\u6027\u3084\u4e88\u5f8c\u3068\u306e\u95a2\u9023\u3092\u8abf\u3079\u307e\u3059\u3002
\n\u306a\u304a\u3001\u672c\u8abf\u67fb\u306b\u95a2\u3059\u308b\u82e6\u60c5\u7b49\u306b\u3064\u3044\u3066\u306f\u3001\u300c\u554f\u3044\u5408\u308f\u305b\u5148\u300d\u3082\u3057\u304f\u306f\u53d7\u8a3a\u3055\u308c\u305f\u8a3a\u7642\u79d1\u307e\u3067\u304a\u7533\u3057\u51fa\u304f\u3060\u3055\u3044\u3002\u307e\u305f\u3001\u500b\u4eba\u60c5\u5831\u306e\u958b\u793a\u3084\u8a02\u6b63\u7b49\u3092\u8981\u6c42\u3055\u308c\u308b\u5834\u5408\u306b\u306f\u3001\u53d7\u8a3a\u3055\u308c\u305f\u8a3a\u7642\u79d1\u307e\u3067\u304a\u7533\u3057\u51fa\u304f\u3060\u3055\u3044\u3002 \u305d\u308c\u306b\u3088\u308b\u4e0d\u5229\u76ca\u306f\u751f\u3058\u307e\u305b\u3093\u3002
\n\u5bfe\u8c61\u8005\u304c\u5e0c\u671b\u3055\u308c\u308b\u5834\u5408\u306f\u3001\u7814\u7a76\u8a08\u753b\u66f8\u53ca\u3073\u7814\u7a76\u306e\u65b9\u6cd5\u306b\u95a2\u3059\u308b\u8cc7\u6599\u3092\u5165\u624b\u307e\u305f\u306f\u95b2\u89a7\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u306e\u3067\u3001\u4e0b\u8a18\u9023\u7d61\u5148\u307e\u3067\u3054\u9023\u7d61\u304f\u3060\u3055\u3044\u3002<\/p>\n<\/section>\n

\n

\u500b\u4eba\u60c5\u5831\u306e\u7ba1\u7406\u306b\u3064\u3044\u3066<\/h4>\n

\u672c\u7814\u7a76\u3067\u306f\u500b\u4eba\u60c5\u5831\u6f0f\u6d29\u3092\u9632\u3050\u305f\u3081\u3001\u6c0f\u540d\u3001\u30ab\u30eb\u30c6\u756a\u53f7\u306a\u3069\u306e\u500b\u4eba\u3092\u7279\u5b9a\u3067\u304d\u308b\u60c5\u5831\u3092\u524a\u9664\u3057\u305f\u4e0a\u3067\u3001\u30c7\u30fc\u30bf\u306e\u6570\u5b57\u5316\u306a\u3069\u306e\u53b3\u683c\u306a\u5bfe\u7b56\u3092\u53d6\u3063\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u672c\u7814\u7a76\u306e\u5b9f\u65bd\u904e\u7a0b\u53ca\u3073\u305d\u306e\u7d50\u679c\u306e\u516c\u8868\uff08\u5b66\u4f1a\u3084\u8ad6\u6587\u7b49\uff09\u306e\u969b\u306b\u306f\u3001\u60a3\u8005\u3055\u3093\u3092\u7279\u5b9a\u3067\u304d\u308b\u60c5\u5831\u306f\u4e00\u5207\u542b\u307e\u308c\u307e\u305b\u3093\u3002<\/p>\n<\/section>\n

\n

\u500b\u4eba\u60c5\u5831\u306e\u53d6\u6271\u3044\u306b\u3064\u3044\u3066<\/h4>\n

\u5bfe\u8c61\u8005\u306e\u30ab\u30eb\u30c6\u306e\u60c5\u5831\u3092\u3053\u306e\u7814\u7a76\u306b\u4f7f\u7528\u3059\u308b\u969b\u306b\u306f\u3001\u5bfe\u8c61\u8005\u306e\u304a\u540d\u524d\u306e\u4ee3\u308f\u308a\u306b\u7814\u7a76\u7528\u306e\u756a\u53f7\u3092\u4ed8\u3051\u3066\u53d6\u308a\u6271\u3044\u307e\u3059\u3002\u5bfe\u8c61\u8005\u3068\u7814\u7a76\u7528\u306e\u756a\u53f7\u3092\u7d50\u3073\u3064\u3051\u308b\u5bfe\u5fdc\u8868\u306e\u30d5\u30a1\u30a4\u30eb\u306b\u306f\u30d1\u30b9\u30ef\u30fc\u30c9\u3092\u8a2d\u5b9a\u3057\u3001\u4e5d\u5dde\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u9662\u75c5\u614b\u6a5f\u80fd\u5185\u79d1\u5b66\u5206\u91ce\u5185\u306e\u30a4\u30f3\u30bf\u30fc\u30cd\u30c3\u30c8\u306b\u63a5\u7d9a\u3067\u304d\u306a\u3044\u30d1\u30bd\u30b3\u30f3\u306b\u4fdd\u5b58\u3057\u307e\u3059\u3002\u3053\u306e\u30d1\u30bd\u30b3\u30f3\u304c\u8a2d\u7f6e\u3055\u308c\u3066\u3044\u308b\u90e8\u5c4b\u306f\u3001\u540c\u5206\u91ce\u306e\u8077\u54e1\u306b\u3088\u3063\u3066\u5165\u5ba4\u304c\u7ba1\u7406\u3055\u308c\u3066\u304a\u308a\u3001\u7b2c\u4e09\u8005\u304c\u7acb\u3061\u5165\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002
\n\u307e\u305f\u3001\u3053\u306e\u7814\u7a76\u306e\u6210\u679c\u3092\u767a\u8868\u3057\u305f\u308a\u3001\u305d\u308c\u3092\u5143\u306b\u7279\u8a31\u7b49\u306e\u7533\u8acb\u3092\u3057\u305f\u308a\u3059\u308b\u5834\u5408\u306b\u3082\u3001\u5bfe\u8c61\u8005\u304c\u7279\u5b9a\u3067\u304d\u308b\u60c5\u5831\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002
\n\u3053\u306e\u7814\u7a76\u306b\u3088\u3063\u3066\u53d6\u5f97\u3057\u305f\u60c5\u5831\u306f\u3001\u4e5d\u5dde\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u9662\u75c5\u614b\u6a5f\u80fd\u5185\u79d1\u5b66\u5206\u91ce\u30fb\u6559\u6388\u30fb\u5317\u5712\u3000\u5b5d\u6210\u306e\u8cac\u4efb\u306e\u4e0b\u3001\u53b3\u91cd\u306a\u7ba1\u7406\u3092\u884c\u3044\u307e\u3059\u3002<\/p>\n<\/section>\n

\n

\u7814\u7a76\u671f\u9593<\/h4>\n

\u7814\u7a76\u3092\u884c\u3046\u671f\u9593\u306f\u627f\u8a8d\u65e5\u3088\u308a\u5e73\u621032\u5e743\u670831\u65e5\u307e\u3067\u3067\u3059\u3002<\/p>\n<\/section>\n

\n

\u533b\u5b66\u4e0a\u306e\u8ca2\u732e<\/h4>\n

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\n

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\n

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\n \u4e5d\u5dde\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u9662\u75c5\u614b\u6a5f\u80fd\u5185\u79d1\u5b66\u5206\u91ce \u52a9\u6559 \u9ce5\u5de3\u525b\u5f18
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\n

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